Egg granulomas in portal presinusoidal vessels result in hepatomegaly, splenomegaly, varices, ascites and fibrosis; those in the mesenteric distribution produce protein-losing enteropathies, malabsorption anemias, hemorrhagic intestinal polyps and fibrosis. Aberrant or embolic lodgment of eggs may produce lesions in a variety of other tissues, including the kidney, lung, central nervous system (CNS) and, rarely, the skin. When skin lesions occur, they are most commonly due to S haematobium; genital and perigenital sites are more frequent and periumbilical less frequent sites of involvement. The lesions may be papules, macules, or, especially in the female genitalia, warty tumors. Cutaneous lesions may be asymptomatic, pruritic or painful. Complications of disease may include ulcerations, fissures, multiple sinuses, fistulae and fibrosis.