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Fortuitously, the only dengue viruses ever to infect the Cuban population ages 3 – 40 years, were DENV 1 in 1977-9 and DENV 2 in 1981. Epidemiological studies showed that rates of infection for these viruses were the same in all age and ethnicity categories (Guzman MG et al AJTMH 42:179-184, 1990) and thus, age-specific DHF/DSS attack rates per 10,000 secondary dengue infections measure intrinsic age-specific susceptibility to dengue vascular permeability. Note that case fatality rates in the elderly exceed reported DHF/DSS attack rates.