The pathogenesis of catheter-related infections is multifactorial and complex ), but available scientific data show that most catheter-related infections appear to result from migration of skin organisms at the insertion site into the cutaneous catheter tract with eventual colonization of the catheter tip.There is a smaller, but growing, body of data to suggest that contamination of the catheter hub also is an important contributor to intraluminal colonization of catheters, particularly long-term catheters.