All there is to know about inhalation exposure chambers was written by Silver in 1946. (1,2,3,4) Anyone starting an inhalation study without reading these articles is making a big mistake.

1. Silver, S. D. Constant gassing chambers: principles influencing design and operation. J. Lab. Clin. Med. 31, 1153-1161, 1946.

2 .MacFarland has reviewed Silvers article and expanded it. See MacFarland, H. N. Designs and operational characteristics of inhalation exposure equipment - A review. Fund. Appl. Toxicol. 3, 603-613, 1983.

3. There is also a report with many details. See Fraser, D. A., Bales, R. E., Lippman, M. and Stokinger, H. E. Exposure chambers for research in animal inhalation. Public Health Monograph No. 57, 1959.

4. See also: Drew, R. T. and Laskin, S. Environmental inhalation chambers. In: Methods of Animal Experimentation. W. I. Gay, Ed., Academic Press, N.Y., p. 1-41, 1973.